Arsenal are up against Dutch side PSV in the first leg of the UEFA Champions League last 16, seeking to recover from a slump in form that has seen them fail to win their last two games.
The Gunners’ dream of a first league title in 21 years appears over after falling 13 points behind runaway leaders Liverpool.
Conquering Europe for the first time now appears their only chance of ending a five-year trophy drought and a kind last-16 draw with PSV Eindhoven could buy Mikel Arteta time to get some of his key attackers back.
Kai Havertz and Gabriel Jesus have been ruled out for the rest of the season with serious hamstring and knee injuries respectively.
But Bukayo Saka and Gabriel Martinelli could return for the quarter-finals next month should Arsenal progress.
In another mouth-watering tie on Tuesday, Real Madrid are home to Atletico in a Spanish derby.
Champions League Last 16 Ties
See the full fixtures for the first leg of the Champions League round of 16 tie:
Club Brugge (BEL) v Aston Villa (ENG)
Borussia Dortmund (GER) v Lille (FRA)
PSV Eindhoven (NED) v Arsenal (ENG)
Real Madrid (ESP) v Atletico Madrid (ESP).