Manchester United’s 2-0 defeat at Tottenham on Wednesday left them trailing 15 points behind Guardiola’s City side at the top of the table with only 13 games left to play.
Jose Mourinho admitted City are now uncatchable but he remains desperate to finish ahead of the chasing pack.
Ahead of Man City’s game against Burnley at Turf Moor on Saturday, Guardiola was asked if he would concede the title in Mourinho’s position.
He replied: “No, I don’t think so. That is not going to happen.
“We play every game to give sense to what we are doing. I know the 15-point distance is quite big at the moment. It’s the same gap from six games ago.
“In football and in sport anything can happen. You are good today but tomorrow you are bad.
“The most important thing we have done is focus. In my experience until everything is done, you have to be prepared for anything to happen.”
